Endocrine Abstracts

Introduction: Parathyroid tumors are the most common (90%) and usually the first manifestation feature of MEN1 syndrome. The occurrence of anterior pituitary tumors in MEN1 syndrome may range between 10% and 60%. Pituitary involvement includes the initial manifestation of MEN1 syndrome in 10% to 25% of individuals and usually show more aggressive behavior; 20% secrete prolactin, fewer than 10% secrete GH, 5% secrete ACTH, and the remainder appear to ...

Aim: To know if Tg levels after treatment (total thyroidectomy and radioiodine ablation) in the DTC can predict their prognosis in the long term.Material and methods: Basal Tg and Tg after rh-TSH were measured in 229 patients with DTC without any evidence of residual tumour (negative neck ultrasonography) after treatment. The group was followed until tumour recurrence or, if recurrence was not found, a minimum of 12 month (mean ± SD =63±37 mont...

Introduction and objective: Clinically nonfunctional pituitary adenomas are relatively an uncommon disease. The aim of this work is to describe the clinical characteristics and to review the results of transsphenoidal surgery (TS) of pituitary adenomas in a reference centre.Methods: A retrospective study (1995–2014) of 66 patients (50% men) diagnosed with pituitary adenomas by a magnetic resonance imaging (MRI) was conducted. demographic, clinical, ...

Introduction: Surgery is the primary therapy in most acromelagic patients. When persistent disease is observed, adjuvant medical therapy is used. Pasireotide is a somatostatin analogue (SSA) not approved for acromegaly therapy yet, but with a potentially better response, given that it binds to four out of five somatostatin receptors.Materials and methods: We present the case of an acromegalic patient with resistance to many therapies and response to trea...

Introduction: The presence of undetectable serum levels of stimulated thyroglobulin (Tg) with negative imaging tests is the criterion used to define remission in low-risk differentiated thyroid cancer (DTC). Most guidelines recommend 131-I ablation after thyroidectomy to remove any possible residual thyroid tissue. Our aim was to know how often undetectable Tg levels are achieved before ablation to avoid unnecessary radiation treatments.Patients and meth...

The Spanish acromegaly registry (REA) is an online epidemiological database created in 1997 to collect clinical and biochemical data of patients with acromegaly followed in Spain.Aim: To study trends in acromegaly treatment over time in Spain.Methods: REA is an online database in which registered endocrinologists collect data from all acromegalic patients seen at their practices in Spain. In the last year the neuroendocrine group o...

Primary lymphomas of the thyroid are uncommon tumours, constituting fewer than 2% of all thyroid malignancies. For this reason their clinical features are not very well known. It seems that most of them arise in patients who have chronic autoimmune thyroiditis.From our patients with primary thyroid cancer since 1995, we selected those with pathological diagnosis of thyroid lymphoma. Epidemiological data, clinical features and response to treatment were a...

Background: Patients with Cushing’s syndrome (CS) in remission show residual cardiometabolic derangements leading to increased cardiovascular risk. Impaired characteristics of gut microbiome (dysbiosis), such as richness, diversity and composition, have been associated with several cardiometabolic risk factors, including obesity, insulin resistance and atherosclerosis. Whether CS patients present with intestinal dysbiosis is currently unknown. Our study was aimed at evalu...

Pseudohypoparathyroidism (PHP) is a term applied to a heterogeneous group of disorders whose common feature is resistance to parathyroid hormone. Most of the PHP forms are caused by defects in GNAS: PHP-Ia (characterized by PTH and TSH resistance with Albright Hereditary Osteodystrophy) is caused by heterozygous inactivating mutations in those exons of GNAS encoding the α subunit of the stimulatory G-protein, and the autosomal dominant form of PHP-Ib (PTH an...

Aim: To determine, in type 1 diabetes mellitus (T1DM) patients, if there is any relationship between the age at onset and the number of HLA risk alleles for T1DM (DRB1*03 and DRB1*04).Methods: Retrospective study. We selected patients with T1DM diagnosis (pancreatic autoimmunity and insulin-dependent diabetes) and age at onset >15 years, identifying 275 subjects (59.6% men and 40.4% women), with a median age at onset of 31 years (interquartile range ...